The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model

The endoplasmic reticulum (ER) has a major role in protein folding. The accumulation of unfolded proteins in the ER induces a stress, which can be resolved by the unfolded protein response (UPR). Chronicity of ER stress leads to UPR-induced apoptosis and in turn to an unbalance of tissue homeostasis...

Descripción completa

Detalles Bibliográficos
Autores principales: Demay, Y, Perochon, J, Szuplewski, S, Mignotte, B, Gaumer, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649510/
https://www.ncbi.nlm.nih.gov/pubmed/25299777
http://dx.doi.org/10.1038/cddis.2014.403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649510/
https://www.ncbi.nlm.nih.gov/pubmed/25299777
http://dx.doi.org/10.1038/cddis.2014.403

Ejemplares similares