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Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism

Human papillomavirus (HPV) is causative for a new and increasing form of head and neck squamous cell carcinomas (HNSCCs). Although localised HPV-positive cancers have a favourable response to radio-chemotherapy (RT/CT), the impact of HPV in advanced or metastatic HNSCC remains to be defined and targ...

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Detalles Bibliográficos
Autores principales: Bullenkamp, J, Raulf, N, Ayaz, B, Walczak, H, Kulms, D, Odell, E, Thavaraj, S, Tavassoli, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649534/
https://www.ncbi.nlm.nih.gov/pubmed/25341043
http://dx.doi.org/10.1038/cddis.2014.455