Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway

Mutations in tuberous sclerosis (TSC) genes cause the genetic disorder TSC, as well as other neoplasms, including lymphangioleiomyomatosis (LAM) and angiomyolipomas (AMLs). AMLs are benign renal tumors occur both in sporadic LAM and in TSC. As they carry the same mutations, AML cell lines serve as a...

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Detalles Bibliográficos
Autores principales: Makovski, V, Jacob-Hirsch, J, Gefen-Dor, C, Shai, B, Ehrlich, M, Rechavi, G, Kloog, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649829/
https://www.ncbi.nlm.nih.gov/pubmed/25476905
http://dx.doi.org/10.1038/cddis.2014.502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649829/
https://www.ncbi.nlm.nih.gov/pubmed/25476905
http://dx.doi.org/10.1038/cddis.2014.502

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