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Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression

The human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL). HTLV-1 Tax has been shown to have a prosurvival role in infected T cells by enhancing expression of the Bcl-2 family of antiapoptotic proteins. In this study, we show that the expression of proapo...

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Detalles Bibliográficos
Autores principales: Mühleisen, A, Giaisi, M, Köhler, R, Krammer, P H, Li-Weber, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649845/
https://www.ncbi.nlm.nih.gov/pubmed/25522269
http://dx.doi.org/10.1038/cddis.2014.536