Suppression of BRCA1 sensitizes cells to proteasome inhibitors

BRCA1 is a multifunctional protein best known for its role in DNA repair and association with breast and ovarian cancers. To uncover novel biologically significant molecular functions of BRCA1, we tested a panel of 198 approved and experimental drugs to inhibit growth of MDA-MB-231 breast cancer cel...

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Detalles Bibliográficos
Autores principales: Gu, Y, Bouwman, P, Greco, D, Saarela, J, Yadav, B, Jonkers, J, Kuznetsov, S G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649846/
https://www.ncbi.nlm.nih.gov/pubmed/25522274
http://dx.doi.org/10.1038/cddis.2014.537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649846/
https://www.ncbi.nlm.nih.gov/pubmed/25522274
http://dx.doi.org/10.1038/cddis.2014.537

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