Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for anticancer therapy; however, non-small-cell lung carcinoma (NSCLC) cells are relatively TRAIL resistant. Identification of small molecules that can restore NSCLC susceptibility to TRAIL-induced apoptosis is mean...

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Detalles Bibliográficos
Autores principales: Shi, Y-L, Feng, S, Chen, W, Hua, Z-C, Bian, J-J, Yin, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649849/
https://www.ncbi.nlm.nih.gov/pubmed/25522273
http://dx.doi.org/10.1038/cddis.2014.547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649849/
https://www.ncbi.nlm.nih.gov/pubmed/25522273
http://dx.doi.org/10.1038/cddis.2014.547

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