CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

Chronic hepatitis B virus (HBV) infection is prevalent, deadly, and seldom cured due to the persistence of viral episomal DNA (cccDNA) in infected cells. Newly developed genome engineering tools may offer the ability to directly cleave viral DNA, thereby promoting viral clearance. Here, we show that...

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Detalles Bibliográficos
Autores principales: Ramanan, Vyas, Shlomai, Amir, Cox, David B.T., Schwartz, Robert E., Michailidis, Eleftherios, Bhatta, Ankit, Scott, David A., Zhang, Feng, Rice, Charles M., Bhatia, Sangeeta N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649911/
https://www.ncbi.nlm.nih.gov/pubmed/26035283
http://dx.doi.org/10.1038/srep10833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649911/
https://www.ncbi.nlm.nih.gov/pubmed/26035283
http://dx.doi.org/10.1038/srep10833

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