Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax

The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation, certain BH3-only proteins can directly bind and activate Bak and Bax to induce conformation change, oligomerization and pore formation in mito...

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Detalles Bibliográficos
Autores principales: Hockings, C, Anwari, K, Ninnis, R L, Brouwer, J, O'Hely, M, Evangelista, M, Hinds, M G, Czabotar, P E, Lee, E F, Fairlie, W D, Dewson, G, Kluck, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650538/
https://www.ncbi.nlm.nih.gov/pubmed/25906158
http://dx.doi.org/10.1038/cddis.2015.105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650538/
https://www.ncbi.nlm.nih.gov/pubmed/25906158
http://dx.doi.org/10.1038/cddis.2015.105

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