In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression. However, the long-sustained conviction that senescence is a truly irreversibl...

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Detalles Bibliográficos
Autores principales: Leikam, C, Hufnagel, A L, Otto, C, Murphy, D J, Mühling, B, Kneitz, S, Nanda, I, Schmid, M, Wagner, T U, Haferkamp, S, Bröcker, E-B, Schartl, M, Meierjohann, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650540/
https://www.ncbi.nlm.nih.gov/pubmed/25837487
http://dx.doi.org/10.1038/cddis.2015.71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650540/
https://www.ncbi.nlm.nih.gov/pubmed/25837487
http://dx.doi.org/10.1038/cddis.2015.71

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