Negative feedback loop between p66(Shc) and ZEB1 regulates fibrotic EMT response in lung cancer cells

The epithelial-to-mesenchymal transition (EMT) program is crucial for the epithelial cancer progression and fibrotic diseases. Our previous work has demonstrated that p66(Shc), a focal adhesion-associated adaptor protein, is frequently downregulated in lung cancers and its depletion promotes metasta...

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Detalles Bibliográficos
Autores principales: Li, X, Gao, D, Wang, H, Yang, J, Yan, X, Liu, Z, Ma, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650543/
https://www.ncbi.nlm.nih.gov/pubmed/25837484
http://dx.doi.org/10.1038/cddis.2015.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650543/
https://www.ncbi.nlm.nih.gov/pubmed/25837484
http://dx.doi.org/10.1038/cddis.2015.74

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