Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs

Many cancer drugs are toxic to cells by activating apoptotic pathways. Previous studies have shown that mitochondria have key roles in apoptosis in mammalian cells, but the role of mitochondrial DNA (mtDNA) copy number variation in the pathogenesis of tumor cell apoptosis remains largely unknown. We...

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Detalles Bibliográficos
Autores principales: Mei, H, Sun, S, Bai, Y, Chen, Y, Chai, R, Li, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650546/
https://www.ncbi.nlm.nih.gov/pubmed/25837486
http://dx.doi.org/10.1038/cddis.2015.78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650546/
https://www.ncbi.nlm.nih.gov/pubmed/25837486
http://dx.doi.org/10.1038/cddis.2015.78

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