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Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B

As a gram-positive, spore-forming anaerobic bacillus, Clostridium difficile (C. difficile) is responsible for severe and fatal pseudomembranous colitis, and poses the most urgent antibiotic resistance threat worldwide. Epidemic C. difficile is the leading cause of antibiotic-associated diarrhoea glo...

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Detalles Bibliográficos
Autores principales: Yuan, Pengfei, Zhang, Hongmin, Cai, Changzu, Zhu, Shiyou, Zhou, Yuexin, Yang, Xiaozhou, He, Ruina, Li, Chan, Guo, Shengjie, Li, Shan, Huang, Tuxiong, Perez-Cordon, Gregorio, Feng, Hanping, Wei, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650570/
https://www.ncbi.nlm.nih.gov/pubmed/25547119
http://dx.doi.org/10.1038/cr.2014.169