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G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition
In vertebrates, embryonic hematopoietic stem and progenitor cells (HSPCs) are derived from a subset of endothelial cells, the hemogenic endothelium (HE), through the endothelial-to-hematopoietic transition (EHT). Notch signaling is essential for HSPC development during embryogenesis across vertebrat...
Autores principales: | Zhang, Panpan, He, Qiuping, Chen, Dongbo, Liu, Weixiao, Wang, Lu, Zhang, Chunxia, Ma, Dongyuan, Li, Wei, Liu, Bing, Liu, Feng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650626/ https://www.ncbi.nlm.nih.gov/pubmed/26358189 http://dx.doi.org/10.1038/cr.2015.109 |
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