Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

The BH3-only protein Bim is a potent direct activator of the proapoptotic effector protein Bax, but the structural basis for its activity has remained poorly defined. Here we describe the crystal structure of the BimBH3 peptide bound to BaxΔC26 and structure-based mutagenesis studies. Similar to Bid...

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Detalles Bibliográficos
Autores principales: Robin, A Y, Krishna Kumar, K, Westphal, D, Wardak, A Z, Thompson, G V, Dewson, G, Colman, P M, Czabotar, P E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650713/
https://www.ncbi.nlm.nih.gov/pubmed/26158515
http://dx.doi.org/10.1038/cddis.2015.141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650713/
https://www.ncbi.nlm.nih.gov/pubmed/26158515
http://dx.doi.org/10.1038/cddis.2015.141

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