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Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility
The Berardinelli–Seip congenital lipodystrophy type 2 (Bscl2, seipin) gene is involved in adipogenesis. Bscl2(−/−) males were infertile but had normal mating behavior. Both Bscl2(−/−) cauda epididymis sperm count and sperm motility were ~20 × less than control. Bscl2(−/−) seminiferous tubules had re...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650735/ https://www.ncbi.nlm.nih.gov/pubmed/26181198 http://dx.doi.org/10.1038/cddis.2015.188 |