Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT

Gefitinib efficiency in non-small-cell lung cancer (NSCLC) therapy is limited due to development of drug resistance. The molecular mechanisms of gefitinib resistance remain still unclear. In this study, we first found that connexin 26 (Cx26) is the predominant Cx isoform expressed in various NSCLC c...

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Detalles Bibliográficos
Autores principales: Yang, J, Qin, G, Luo, M, Chen, J, Zhang, Q, Li, L, Pan, L, Qin, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650742/
https://www.ncbi.nlm.nih.gov/pubmed/26203858
http://dx.doi.org/10.1038/cddis.2015.197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650742/
https://www.ncbi.nlm.nih.gov/pubmed/26203858
http://dx.doi.org/10.1038/cddis.2015.197

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