Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

Hepatocyte damage and inflammation in monocytes/macrophages are central to the pathogenesis of alcoholic hepatitis (AH). MicroRNAs (miRNAs) regulate all of these processes. MiRNA-122 is abundantly expressed in hepatocytes while monocytes/macrophages have low levels. The role of exosomes in AH and po...

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Detalles Bibliográficos
Autores principales: Momen-Heravi, Fatemeh, Bala, Shashi, Kodys, Karen, Szabo, Gyongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650752/
https://www.ncbi.nlm.nih.gov/pubmed/25973575
http://dx.doi.org/10.1038/srep09991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650752/
https://www.ncbi.nlm.nih.gov/pubmed/25973575
http://dx.doi.org/10.1038/srep09991

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