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In silico evaluation and exploration of antibiotic tuberculosis treatment regimens

BACKGROUND: Improvement in tuberculosis treatment regimens requires selection of antibiotics and dosing schedules from a large design space of possibilities. Incomplete knowledge of antibiotic and host immune dynamics in tuberculosis granulomas impacts clinical trial design and success, and variatio...

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Detalles Bibliográficos
Autores principales: Pienaar, Elsje, Dartois, Véronique, Linderman, Jennifer J., Kirschner, Denise E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650854/
https://www.ncbi.nlm.nih.gov/pubmed/26578235
http://dx.doi.org/10.1186/s12918-015-0221-8