Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration

BACKGROUND: Microglia reactivity is a hallmark of retinal degenerations and overwhelming microglial responses contribute to photoreceptor death. Minocycline, a semi-synthetic tetracycline analog, has potent anti-inflammatory and neuroprotective effects. Here, we investigated how minocycline affects...

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Detalles Bibliográficos
Autores principales: Scholz, Rebecca, Sobotka, Markus, Caramoy, Albert, Stempfl, Thomas, Moehle, Christoph, Langmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650866/
https://www.ncbi.nlm.nih.gov/pubmed/26576678
http://dx.doi.org/10.1186/s12974-015-0431-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650866/
https://www.ncbi.nlm.nih.gov/pubmed/26576678
http://dx.doi.org/10.1186/s12974-015-0431-4

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