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Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration

BACKGROUND: Microglia reactivity is a hallmark of retinal degenerations and overwhelming microglial responses contribute to photoreceptor death. Minocycline, a semi-synthetic tetracycline analog, has potent anti-inflammatory and neuroprotective effects. Here, we investigated how minocycline affects...

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Detalles Bibliográficos
Autores principales:	Scholz, Rebecca, Sobotka, Markus, Caramoy, Albert, Stempfl, Thomas, Moehle, Christoph, Langmann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650866/ https://www.ncbi.nlm.nih.gov/pubmed/26576678 http://dx.doi.org/10.1186/s12974-015-0431-4

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