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Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation

BACKGROUND: Hepatitis C Virus (HCV) infection is associated with chronically evolving disease and development of hepatocellular carcinoma (HCC), albeit the mechanism of HCC induction by HCV is still controversial. The nucleocapsid (core) protein of HCV has been shown to be directly implicated in cel...

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Detalles Bibliográficos
Autores principales: Mileo, Anna Maria, Mattarocci, Stefano, Matarrese, Paola, Anticoli, Simona, Abbruzzese, Claudia, Catone, Stefania, Sacco, Rodolfo, Paggi, Marco G., Ruggieri, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650920/
https://www.ncbi.nlm.nih.gov/pubmed/26576645
http://dx.doi.org/10.1186/s13046-015-0255-1