Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIII

Recombinant FVIII manufacturing is characterized by poor product stability and low yields. Codon-optimization of transgenes accelerates translation by exploiting the synonymous codon usage bias of a species. However, this can alter the performance of the final product. Additionally, the effects of t...

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Detalles Bibliográficos
Autores principales: Crawford, Bredon, Ozelo, Margareth C, Ogiwara, Kenichi, Ahlin, James, Albanez, Silvia, Hegadorn, Carol, Harpell, Lori, Hough, Christine, Lillicrap, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650998/
https://www.ncbi.nlm.nih.gov/pubmed/26636112
http://dx.doi.org/10.1038/mtm.2015.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650998/
https://www.ncbi.nlm.nih.gov/pubmed/26636112
http://dx.doi.org/10.1038/mtm.2015.33

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