The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion

The conversion of the prion protein (PrP(C)) into prions plays a key role in transmissible spongiform encephalopathies. Despite the importance for pathogenesis, the mechanism of prion formation has escaped detailed characterization due to the insoluble nature of prions. PrP(C) interacts with copper...

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Detalles Bibliográficos
Autores principales: Giachin, Gabriele, Mai, Phuong Thao, Tran, Thanh Hoa, Salzano, Giulia, Benetti, Federico, Migliorati, Valentina, Arcovito, Alessandro, Longa, Stefano Della, Mancini, Giordano, D’Angelo, Paola, Legname, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651146/
https://www.ncbi.nlm.nih.gov/pubmed/26482532
http://dx.doi.org/10.1038/srep15253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651146/
https://www.ncbi.nlm.nih.gov/pubmed/26482532
http://dx.doi.org/10.1038/srep15253

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