XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

Schmid metaphyseal chondrodysplasia (MCDS) involves dwarfism and growth plate cartilage hypertrophic zone expansion resulting from dominant mutations in the hypertrophic zone collagen, Col10a1. Mouse models phenocopying MCDS through the expression of an exogenous misfolding protein in the endoplasmi...

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Detalles Bibliográficos
Autores principales: Cameron, Trevor L., Bell, Katrina M., Gresshoff, Irma L., Sampurno, Lisa, Mullan, Lorna, Ermann, Joerg, Glimcher, Laurie H., Boot-Handford, Raymond P., Bateman, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651170/
https://www.ncbi.nlm.nih.gov/pubmed/26372225
http://dx.doi.org/10.1371/journal.pgen.1005505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651170/
https://www.ncbi.nlm.nih.gov/pubmed/26372225
http://dx.doi.org/10.1371/journal.pgen.1005505

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