A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia

Childhood acute lymphoblastic leukemia (ALL) with t(12;21), which results in expression of the ETV6/RUNX1 fusion gene, is the most common chromosomal lesion in precursor-B (pre-B) ALL. We identified 17 microRNAs that were downregulated in ETV6/RUNX1 (+) compared with ETV6/RUNX1 (−) clinical samples....

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Detalles Bibliográficos
Autores principales: Yang, Yung-Li, Yen, Ching-Tzu, Pai, Chen-Hsueh, Chen, Hsuan-Yu, Yu, Sung-Liang, Lin, Chien-Yu, Hu, Chung-Yi, Jou, Shiann-Tarng, Lin, Dong-Tsamn, Lin, Shu-Rung, Lin, Shu-Wha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651427/
https://www.ncbi.nlm.nih.gov/pubmed/26580398
http://dx.doi.org/10.1371/journal.pone.0142863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651427/
https://www.ncbi.nlm.nih.gov/pubmed/26580398
http://dx.doi.org/10.1371/journal.pone.0142863

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