Investigating DNA Binding and Conformational Variation in Temperature Sensitive p53 Cancer Mutants Using QM-MM Simulations

The tp53 gene is found to be mutated in 50% of all the cancers. The p53 protein, a product of tp53 gene, is a multi-domain protein. It consists of a core DNA binding domain (DBD) which is responsible for its binding and transcription of downstream target genes. The mutations in p53 protein are respo...

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Detalles Bibliográficos
Autores principales: Koulgi, Shruti, Achalere, Archana, Sonavane, Uddhavesh, Joshi, Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651507/
https://www.ncbi.nlm.nih.gov/pubmed/26579714
http://dx.doi.org/10.1371/journal.pone.0143065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651507/
https://www.ncbi.nlm.nih.gov/pubmed/26579714
http://dx.doi.org/10.1371/journal.pone.0143065

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