IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome

The HBV covalently closed circular DNA (cccDNA) is organized as a mini-chromosome in the nuclei of infected hepatocytes by histone and non-histone proteins. Transcription from the cccDNA of the RNA replicative intermediate termed pre-genome (pgRNA), is the critical step for genome amplification and...

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Detalles Bibliográficos
Autores principales: Palumbo, Gianna Aurora, Scisciani, Cecilia, Pediconi, Natalia, Lupacchini, Leonardo, Alfalate, Dulce, Guerrieri, Francesca, Calvo, Ludovica, Salerno, Debora, Di Cocco, Silvia, Levrero, Massimo, Belloni, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651563/
https://www.ncbi.nlm.nih.gov/pubmed/26580974
http://dx.doi.org/10.1371/journal.pone.0142599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651563/
https://www.ncbi.nlm.nih.gov/pubmed/26580974
http://dx.doi.org/10.1371/journal.pone.0142599

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