High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New comput...

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Autores principales: Goronzy, Jörg J., Qi, Qian, Olshen, Richard A., Weyand, Cornelia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652363/
https://www.ncbi.nlm.nih.gov/pubmed/26582264
http://dx.doi.org/10.1186/s13073-015-0242-3
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author Goronzy, Jörg J.
Qi, Qian
Olshen, Richard A.
Weyand, Cornelia M.
author_facet Goronzy, Jörg J.
Qi, Qian
Olshen, Richard A.
Weyand, Cornelia M.
author_sort Goronzy, Jörg J.
collection PubMed
description Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.
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spelling pubmed-46523632015-11-20 High-throughput sequencing insights into T-cell receptor repertoire diversity in aging Goronzy, Jörg J. Qi, Qian Olshen, Richard A. Weyand, Cornelia M. Genome Med Comment Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity. BioMed Central 2015-11-19 /pmc/articles/PMC4652363/ /pubmed/26582264 http://dx.doi.org/10.1186/s13073-015-0242-3 Text en © Goronzy et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Goronzy, Jörg J.
Qi, Qian
Olshen, Richard A.
Weyand, Cornelia M.
High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
title High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
title_full High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
title_fullStr High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
title_full_unstemmed High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
title_short High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
title_sort high-throughput sequencing insights into t-cell receptor repertoire diversity in aging
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652363/
https://www.ncbi.nlm.nih.gov/pubmed/26582264
http://dx.doi.org/10.1186/s13073-015-0242-3
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