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Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer
BACKGROUND: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical relevance related to response to therapy. The aim of our study was to investigate the mutation sta...
Autores principales: | Arsenic, Ruza, Treue, Denise, Lehmann, Annika, Hummel, Michael, Dietel, Manfred, Denkert, Carsten, Budczies, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652376/ https://www.ncbi.nlm.nih.gov/pubmed/26587011 http://dx.doi.org/10.1186/s12907-015-0020-6 |
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