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Investigating bisulfite short-read mapping failure with hairpin bisulfite sequencing data
BACKGROUND: DNA methylation is an important epigenetic mark relevant to normal development and disease genesis. A common approach to characterizing genome-wide DNA methylation is using Next Generation Sequencing technology to sequence bisulfite treated DNA. The short sequence reads are mapped to the...
Autores principales: | Porter, Jacob, Sun, Ming-an, Xie, Hehuang, Zhang, Liqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652484/ https://www.ncbi.nlm.nih.gov/pubmed/26576456 http://dx.doi.org/10.1186/1471-2164-16-S11-S2 |
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