The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants()

Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204 (Tyr204) residues in substrate binding, catalysis and inhibition by...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsoumpra, Maria K., Muniz, Joao R., Barnett, Bobby L., Kwaasi, Aaron A., Pilka, Ewa S., Kavanagh, Kathryn L., Evdokimov, Artem, Walter, Richard L., Von Delft, Frank, Ebetino, Frank H., Oppermann, Udo, Russell, R. Graham G., Dunford, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Original Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652608/
https://www.ncbi.nlm.nih.gov/pubmed/26318908
http://dx.doi.org/10.1016/j.bone.2015.08.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652608/
https://www.ncbi.nlm.nih.gov/pubmed/26318908
http://dx.doi.org/10.1016/j.bone.2015.08.020

Ejemplares similares