Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures

Cancer results from dysregulation of multiple steps of gene expression programs. We review how transcriptome profiling has been widely explored for cancer classification and biomarker discovery but resulted in limited clinical impact. Therefore, we discuss alternative and complementary omics approac...

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Detalles Bibliográficos
Autores principales: Modelska, Angelika, Quattrone, Alessandro, Re, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652618/
https://www.ncbi.nlm.nih.gov/pubmed/25832647
http://dx.doi.org/10.1093/bib/bbv013
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author Modelska, Angelika
Quattrone, Alessandro
Re, Angela
author_facet Modelska, Angelika
Quattrone, Alessandro
Re, Angela
author_sort Modelska, Angelika
collection PubMed
description Cancer results from dysregulation of multiple steps of gene expression programs. We review how transcriptome profiling has been widely explored for cancer classification and biomarker discovery but resulted in limited clinical impact. Therefore, we discuss alternative and complementary omics approaches.
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spelling pubmed-46526182015-11-25 Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures Modelska, Angelika Quattrone, Alessandro Re, Angela Brief Bioinform Papers Cancer results from dysregulation of multiple steps of gene expression programs. We review how transcriptome profiling has been widely explored for cancer classification and biomarker discovery but resulted in limited clinical impact. Therefore, we discuss alternative and complementary omics approaches. Oxford University Press 2015-11 2015-03-31 /pmc/articles/PMC4652618/ /pubmed/25832647 http://dx.doi.org/10.1093/bib/bbv013 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Papers
Modelska, Angelika
Quattrone, Alessandro
Re, Angela
Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures
title Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures
title_full Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures
title_fullStr Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures
title_full_unstemmed Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures
title_short Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures
title_sort molecular portraits: the evolution of the concept of transcriptome-based cancer signatures
topic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652618/
https://www.ncbi.nlm.nih.gov/pubmed/25832647
http://dx.doi.org/10.1093/bib/bbv013
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