The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence

La-related protein 1 (LARP1) regulates the stability of many mRNAs. These include 5′TOPs, mTOR-kinase responsive mRNAs with pyrimidine-rich 5′ UTRs, which encode ribosomal proteins and translation factors. We determined that the highly conserved LARP1-specific C-terminal DM15 region of human LARP1 d...

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Detalles Bibliográficos
Autores principales: Lahr, Roni M., Mack, Seshat M., Héroux, Annie, Blagden, Sarah P., Bousquet-Antonelli, Cécile, Deragon, Jean-Marc, Berman, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652764/
https://www.ncbi.nlm.nih.gov/pubmed/26206669
http://dx.doi.org/10.1093/nar/gkv748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652764/
https://www.ncbi.nlm.nih.gov/pubmed/26206669
http://dx.doi.org/10.1093/nar/gkv748

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