Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda

8-Oxo-7,8,-dihydro-2′-deoxyguanosine triphosphate (8-oxo-dGTP) is a major product of oxidative damage in the nucleotide pool. It is capable of mispairing with adenosine (dA), resulting in futile, mutagenic cycles of base excision repair. Therefore, it is critical that DNA polymerases discriminate ag...

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Detalles Bibliográficos
Autores principales: Burak, Matthew J., Guja, Kip E., Garcia-Diaz, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652769/
https://www.ncbi.nlm.nih.gov/pubmed/26220180
http://dx.doi.org/10.1093/nar/gkv760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652769/
https://www.ncbi.nlm.nih.gov/pubmed/26220180
http://dx.doi.org/10.1093/nar/gkv760

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