Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization

Nucleobase modifications dramatically alter nucleic acid structure and thermodynamics. 2-thiouridine (s(2)U) is a modified nucleobase found in tRNAs and known to stabilize U:A base pairs and destabilize U:G wobble pairs. The recently reported crystal structures of s(2)U-containing RNA duplexes do no...

Descripción completa

Detalles Bibliográficos
Autores principales: Larsen, Aaron T., Fahrenbach, Albert C., Sheng, Jia, Pian, Julia, Szostak, Jack W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652770/
https://www.ncbi.nlm.nih.gov/pubmed/26240387
http://dx.doi.org/10.1093/nar/gkv761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652770/
https://www.ncbi.nlm.nih.gov/pubmed/26240387
http://dx.doi.org/10.1093/nar/gkv761

Ejemplares similares