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Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization

Nucleobase modifications dramatically alter nucleic acid structure and thermodynamics. 2-thiouridine (s(2)U) is a modified nucleobase found in tRNAs and known to stabilize U:A base pairs and destabilize U:G wobble pairs. The recently reported crystal structures of s(2)U-containing RNA duplexes do no...

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Detalles Bibliográficos
Autores principales:	Larsen, Aaron T., Fahrenbach, Albert C., Sheng, Jia, Pian, Julia, Szostak, Jack W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652770/ https://www.ncbi.nlm.nih.gov/pubmed/26240387 http://dx.doi.org/10.1093/nar/gkv761

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