Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts

DNA interstrand crosslinks (ICLs) are the primary mechanism for the cytotoxic activity of many clinical anticancer drugs, and numerous strategies for forming ICLs have been developed. One such method is using crosslink-forming oligonucleotides (CFOs). In this study, we designed a 4-amino-6-oxo-2-vin...

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Detalles Bibliográficos
Autores principales: Kusano, Shuhei, Ishiyama, Shogo, Lam, Sik Lok, Mashima, Tsukasa, Katahira, Masato, Miyamoto, Kengo, Aida, Misako, Nagatsugi, Fumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652779/
https://www.ncbi.nlm.nih.gov/pubmed/26245348
http://dx.doi.org/10.1093/nar/gkv797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652779/
https://www.ncbi.nlm.nih.gov/pubmed/26245348
http://dx.doi.org/10.1093/nar/gkv797

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