Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumors

Although mutational inactivation of p53 is found in 50% of all human tumors, a subset of tumors display defective p53 function, but retain wild-type (WT) p53. Here, direct and indirect mechanisms leading to the loss of WT p53 activities are discussed. We summarize the oncogenic roles of iASPP, an in...

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Detalles Bibliográficos
Autores principales: Dong, Peixin, Ihira, Kei, Hamada, Junichi, Watari, Hidemichi, Yamada, Takahiro, Hosaka, Masayoshi, Hanley, Sharon J.B., Kudo, Masataka, Sakuragi, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652980/
https://www.ncbi.nlm.nih.gov/pubmed/26343523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652980/
https://www.ncbi.nlm.nih.gov/pubmed/26343523

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