Cargando…

In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma

Glioblastoma (GBM) is the most lethal brain cancer with profound genomic alterations. While the bona fide tumor suppressor genes such as PTEN, NF1, and TP53 have high frequency of inactivating mutations, there may be the genes with GBM-suppressive roles for which genomic mutation is not a primary ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sa, Jason K., Yoon, Yeup, Kim, Misuk, Kim, Yeonghwan, Cho, Hee Jin, Lee, Jin-Ku, Kim, Gi-Soo, Han, Suji, Kim, Woon Jin, Shin, Yong Jae, Joo, Kyeung Min, Paddison, Patrick J., Ishitani, Tohru, Lee, Jeongwu, Nam, Do-Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652994/ https://www.ncbi.nlm.nih.gov/pubmed/26023737

Ejemplares similares

Targeting the epithelial to mesenchymal transition in glioblastoma: the emerging role of MET signaling
por: Lee, Jin-Ku, et al.
Publicado: (2014)

FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2
por: Lee, Yeri, et al.
Publicado: (2015)

Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme
por: Kang, Wonyoung, et al.
Publicado: (2015)

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma
por: Shin, Yong Jae, et al.
Publicado: (2019)

Anti-SEMA3A Antibody: A Novel Therapeutic Agent to Suppress Glioblastoma Tumor Growth
por: Lee, Jaehyun, et al.
Publicado: (2018)

Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain
por: Lee, Se Jeong, et al.
Publicado: (2015)

NTRK1 Fusion in Glioblastoma Multiforme
por: Kim, Jinkuk, et al.
Publicado: (2014)

Translational Validation of Personalized Treatment Strategy Based on Genetic Characteristics of Glioblastoma
por: Oh, Young Taek, et al.
Publicado: (2014)

The expression of NLK is functionally associated with colorectal cancers (CRC)
por: Chen, Xinyan, et al.
Publicado: (2021)

Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis
por: Lv, Mutian, et al.
Publicado: (2016)

NLK Is a Novel Therapeutic Target for PTEN Deficient Tumour Cells
por: Mendes-Pereira, Ana M., et al.
Publicado: (2012)

NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin
por: Suwei, Dong, et al.
Publicado: (2015)

NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling
por: Masoumi, Katarzyna Chmielarska, et al.
Publicado: (2017)

KML001, a Telomere-Targeting Drug, Sensitizes Glioblastoma Cells to Temozolomide Chemotherapy and Radiotherapy through DNA Damage and Apoptosis
por: Woo, Seon Rang, et al.
Publicado: (2014)

Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain
por: Park, Hyunkyu, et al.
Publicado: (2017)

Erratum to: NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin
por: Suwei, Dong, et al.
Publicado: (2016)

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition
por: Yuan, Hai-Xin, et al.
Publicado: (2015)

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart
por: Liu, Ruijie, et al.
Publicado: (2016)

NLK interacts with 14-3-3ζ to restore the expression of E-cadherin
por: Chen, Jie, et al.
Publicado: (2020)

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
por: Li, Shang-Ze, et al.
Publicado: (2019)

Identification of prognostic biomarkers for glioblastomas using protein expression profiling
por: JUNG, YONG, et al.
Publicado: (2011)

Secretome analysis of patient-derived GBM tumor spheres identifies midkine as a potent therapeutic target
por: Han, Suji, et al.
Publicado: (2019)

Correction: Secretome analysis of patient-derived GBM tumorspheres identifies midkine as a potent therapeutic target
por: Han, Suji, et al.
Publicado: (2020)

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
por: Sa, Jason K., et al.
Publicado: (2020)

Impact of a Recombinant Biocontrol Bacterium, Pseudomonas fluorescens pc78, on Microbial Community in Tomato Rhizosphere
por: Kong, Hyun Gi, et al.
Publicado: (2016)

Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma
por: Nam, Hye Jin, et al.
Publicado: (2021)

472. Prevalence, Risk Factors, and Outcome of Postoperative Clostridium difficile Infection After Orthopedic Surgery
por: Kim, Dong Youn, et al.
Publicado: (2018)

Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells
por: Her, Nam-Gu, et al.
Publicado: (2018)

Sishen Wan(®) Ameliorated Trinitrobenzene-Sulfonic-Acid-Induced Chronic Colitis via NEMO/NLK Signaling Pathway
por: Wang, Hai-Yan, et al.
Publicado: (2019)

ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
por: Yin, Jinlong, et al.
Publicado: (2020)

RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis
por: Kim, Jin Yeop, et al.
Publicado: (2019)

Opposing Activities of LIT-1/NLK and DAF-6/Patched-Related Direct Sensory Compartment Morphogenesis in C. elegans
por: Oikonomou, Grigorios, et al.
Publicado: (2011)

Glioblastoma specific antigens, GD2 and CD90, are not involved in cancer stemness
por: Woo, Seon Rang, et al.
Publicado: (2015)

Anticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis
por: Kim, Dong Geon, et al.
Publicado: (2015)

Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma
por: Choi, Seung Won, et al.
Publicado: (2021)

Ly6G(+) inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model
por: Jeon, Hee-Young, et al.
Publicado: (2019)

Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells
por: Kim, Hyeon Ji, et al.
Publicado: (2021)

Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination
por: You, Hye Jin, et al.
Publicado: (2016)

RNAi-Based Approaches for Pancreatic Cancer Therapy
por: Kim, Min Ju, et al.
Publicado: (2021)

Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma
por: Nam, Yoonhee, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nvnlu5ti1r57nkk7i3h0dimku9