A novel oHSV-1 targeting telomerase reverse transcriptase-positive cancer cells via tumor-specific promoters regulating the expression of ICP4

Virotherapy is a promising strategy for cancer treatment. Using the human telomerase reverse transcriptase promoter, we developed a novel tumor-selective replication oncolytic HSV-1. Here we showed that oHSV1-hTERT virus was cytopathic in telomerase-positive cancer cell lines but not in telomerase-n...

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Detalles Bibliográficos
Autores principales: Zhang, Wen, Ge, Keli, Zhao, Qian, Zhuang, Xiufen, Deng, Zhenling, Liu, Lingling, Li, Jie, Zhang, Yu, Dong, Ying, Zhang, Youhui, Zhang, Shuren, Liu, Binlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653009/
https://www.ncbi.nlm.nih.gov/pubmed/25972362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653009/
https://www.ncbi.nlm.nih.gov/pubmed/25972362

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