Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells

The triple-negative breast cancer (TNBC) subtype is enriched in cancer stem cells (CSCs) and clinically correlated with the highest rate of recurrence. Several studies implicate the RSK pathway as being pivotal for the growth and proliferation of CSCs, which are postulated to drive tumor relapse. We...

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Detalles Bibliográficos
Autores principales: Davies, Alastair H., Reipas, Kristen, Hu, Kaiji, Berns, Rachel, Firmino, Natalie, Stratford, Anna L., Dunn, Sandra E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653026/
https://www.ncbi.nlm.nih.gov/pubmed/26011941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653026/
https://www.ncbi.nlm.nih.gov/pubmed/26011941

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