PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Enhancing the response to interferon could offer an immunological advantage to the host. In support of this concept, we used a modified form of the transcription factor STAT1 to achieve hyper-responsiveness to interferon without toxicity and markedly improve antiviral function in transgenic mice and...

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Detalles Bibliográficos
Autores principales: Zhang, Yong, Mao, Dailing, Roswit, William T, Jin, Xiaohua, Patel, Anand C, Patel, Dhara A, Agapov, Eugene, Wang, Zhepeng, Tidwell, Rose M, Atkinson, Jeffrey J, Huang, Guangming, McCarthy, Ronald, Yu, Jinsheng, Yun, Nadezhda E, Paessler, Slobodan, Lawson, T Glen, Omattage, Natalie S, Brett, Tom J, Holtzman, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653074/
https://www.ncbi.nlm.nih.gov/pubmed/26479788
http://dx.doi.org/10.1038/ni.3279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653074/
https://www.ncbi.nlm.nih.gov/pubmed/26479788
http://dx.doi.org/10.1038/ni.3279

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