Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington’s disease R6/2 model

Mutant huntingtin (mHtt) aggregation in the nucleus is the most readily apparent phenotype and cause of neuronal death in Huntington’s disease (HD). Inhibiting mHtt aggregation reduces cell death in the brain and is thus a promising therapeutic approach. The results of the present study demonstrated...

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Detalles Bibliográficos
Autores principales: Im, Wooseok, Ban, Jae-Jun, Chung, Jin-Young, Lee, Soon-Tae, Chu, Kon, Kim, Manho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653614/
https://www.ncbi.nlm.nih.gov/pubmed/26586297
http://dx.doi.org/10.1038/srep16887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653614/
https://www.ncbi.nlm.nih.gov/pubmed/26586297
http://dx.doi.org/10.1038/srep16887

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