Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication

Potent inhibitors to reverse Botulinum neurotoxins (BoNTs) activity in neuronal cells are currently not available. A better understanding of the substrate recognition mechanism of BoNTs enabled us to design a novel class of peptide inhibitors which were derivatives of the BoNT/A substrate, SNAP25. T...

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Detalles Bibliográficos
Autores principales: Guo, Jiubiao, Wang, Jinglin, Gao, Shan, Ji, Bin, Waichi Chan, Edward, Chen, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653808/
https://www.ncbi.nlm.nih.gov/pubmed/26584873
http://dx.doi.org/10.1038/srep16981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653808/
https://www.ncbi.nlm.nih.gov/pubmed/26584873
http://dx.doi.org/10.1038/srep16981

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