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The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production

The hepatitis C virus (HCV) p7 protein is required for infectious virus production via its role in assembly and ion channel activity. Although NMR structures of p7 have been reported, the location of secondary structural elements and orientation of the p7 transmembrane domains differ among models. F...

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Detalles Bibliográficos
Autores principales: Scull, Margaret A., Schneider, William M., Flatley, Brenna R., Hayden, Robert, Fung, Canny, Jones, Christopher T., van de Belt, Marieke, Penin, François, Rice, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654572/
https://www.ncbi.nlm.nih.gov/pubmed/26588073
http://dx.doi.org/10.1371/journal.ppat.1005297