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Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family
Understanding function and specificity of de-ubiquitylating enzymes (DUBs) is a major goal of current research, since DUBs are key regulators of ubiquitylation events and have been shown to be mutated in human diseases. Most DUBs are cysteine proteases, relying on a catalytic triad of cysteine, hist...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654579/ https://www.ncbi.nlm.nih.gov/pubmed/26588485 http://dx.doi.org/10.1371/journal.pone.0143227 |