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Structural Basis of Template Boundary Definition in Tetrahymena Telomerase

Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template. An essential feature of telomerase catalysis is the str...

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Detalles Bibliográficos
Autores principales: Jansson, Linnea I., Akiyama, Ben M., Ooms, Alexandra, Lu, Cheng, Rubin, Seth M., Stone, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654688/
https://www.ncbi.nlm.nih.gov/pubmed/26436828
http://dx.doi.org/10.1038/nsmb.3101