Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent studies suggest that diffuse midline glioma, H3-K27M mutant, may comprise more than one biological entity. The aim of the study was to determ...

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Detalles Bibliográficos
Autores principales: Castel, David, Philippe, Cathy, Calmon, Raphaël, Le Dret, Ludivine, Truffaux, Nathalène, Boddaert, Nathalie, Pagès, Mélanie, Taylor, Kathryn R., Saulnier, Patrick, Lacroix, Ludovic, Mackay, Alan, Jones, Chris, Sainte-Rose, Christian, Blauwblomme, Thomas, Andreiuolo, Felipe, Puget, Stephanie, Grill, Jacques, Varlet, Pascale, Debily, Marie-Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654747/
https://www.ncbi.nlm.nih.gov/pubmed/26399631
http://dx.doi.org/10.1007/s00401-015-1478-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654747/
https://www.ncbi.nlm.nih.gov/pubmed/26399631
http://dx.doi.org/10.1007/s00401-015-1478-0

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