Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action

BACKGROUND: We have previously shown in pancreatic ductal adenocarcinoma (PDAC) cells that the SRC inhibitors PP2 and PP1 effectively inhibited TGF-β1-mediated cellular responses by blocking the kinase function of the TGF-β type I receptor ALK5 rather than SRC. Here, we investigated the ability of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Bartscht, Tobias, Rosien, Benjamin, Rades, Dirk, Kaufmann, Roland, Biersack, Harald, Lehnert, Hendrik, Gieseler, Frank, Ungefroren, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654868/
https://www.ncbi.nlm.nih.gov/pubmed/26588899
http://dx.doi.org/10.1186/s12943-015-0468-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654868/
https://www.ncbi.nlm.nih.gov/pubmed/26588899
http://dx.doi.org/10.1186/s12943-015-0468-0

Ejemplares similares