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Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action

BACKGROUND: We have previously shown in pancreatic ductal adenocarcinoma (PDAC) cells that the SRC inhibitors PP2 and PP1 effectively inhibited TGF-β1-mediated cellular responses by blocking the kinase function of the TGF-β type I receptor ALK5 rather than SRC. Here, we investigated the ability of t...

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Detalles Bibliográficos
Autores principales:	Bartscht, Tobias, Rosien, Benjamin, Rades, Dirk, Kaufmann, Roland, Biersack, Harald, Lehnert, Hendrik, Gieseler, Frank, Ungefroren, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654868/ https://www.ncbi.nlm.nih.gov/pubmed/26588899 http://dx.doi.org/10.1186/s12943-015-0468-0

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